• Title: The Design and Analysis of Sequential Clinical Trials (Mathematics and Its Applications (Ellis Horwood Ltd))
  • Author: John Whitehead
  • Released: 1992-06-01
  • Language: English
  • Pages: 300
  • ISBN: 0132025655
  • ISBN13: 978-0132025652
  • ASIN: 0132025655
Review "...This book is clear, it provides many details and is well written..." (Statistical Methods in Medical Research, No.11, 2002) --This text refers to an alternate edition.

From the Publisher This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials. --This text refers to an alternate edition.

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